Aluminum salts and the risk of breast cancer

I did not usually copy the articles in other, but here the subject seems to me the most important.

Le sujet fait débat depuis des années. Aujourd’hui une bonne connaissance à moi experte en pharmaco-toxicologie m’a transmit un article sur le sujet.

I sent you copy the sources from the University of Geneva :
The original here

Deodorants containing aluminum salt in suspected breast cancer

GENEVA 13/01 – A study of cell biology, conducted by researchers at the University of Geneva (UNIGE) highlights the adverse effects of aluminum salts (of aluminum chlorhydrate et chlorure of aluminum), present in conventional deodorants, on human mammary cells in vitro. While this study does not constitute a formal proof of liability of aluminum salts in the development of breast cancer, it challenges the safety of these salts on mammary cells.

The increased number of breast cancers in industrialized countries in recent decades is accompanied by changes in the anatomical distribution of this cancer, which develops now mainly in the external part of the mammary gland, near the armpits. This location reopens the question of liability of deodorants containing aluminum salts - whose penetration of the skin has been, in the formation of breast cancer. To date, little or no experimental or epidemiological data were able to strengthen or refute this hypothesis.

A team from the University of Geneva, coordinated by Stefano Mandriota, biology researcher at the Faculty of Medicine, and André-Pascal Sappino, honorary professor and specialist in breast cancer, conducted a series of in vitro experiments revealed that the adverse effects of aluminum salts in human mammary cells.

Adverse effects experienced
Models of normal human mammary epithelial cells were cultured in an environment containing doses of aluminum salts 1 500 to 100 000 times lower than those present in conventional deodorants. After several weeks, researchers found that the aluminum salts have adverse effects on breast cells and cause abnormal behavior, which corresponds to early stages of malignant transformation of cells.

By the phenomenon of contact inhibition, normal cells, placed in culture, stop proliferating when they come into contact with each other. The team at M. Mandriota discovered that mammary cells that were exposed to aluminum salts that lose contact inhibition and continue to multiply : they behave like cells towards malignant transformation.

This study also highlighted the growing number of DNA double-strand DNA in breast cells exposed to aluminum salts, caused by an alteration of the process of cell proliferation. These fractures may be related to the induction of malignant transformation of mammary cells, generated by the aluminum salts.

Furthermore, the researchers analyzed the behavior of breast cells exposed to aluminum salts in agarose gels (soft agar assay). Where normal cells are isolated, cells exposed to aluminum salts form colonies. This behavior is typical of tumor cells and cells towards malignant transformation.

"Although this study does not allow to state that the aluminum salts, present in conventional deodorants, cause the development of breast cancer, it is a scientific proof of the harmfulness of these salts on mammary cells ", Stephen conclut Mandriota.

13/01/2012 – 16h14
Source : University of Geneva